A positive relationship between exposure to heavy metals and development of chronic diseases: A case study from Chile

Cortés, Sandra; Zúñiga-Venegas, Liliana A.; Pancetti, Floria; Covarrubias, Alejandra; Ramírez-Santana, Muriel; Adaros, Héctor; Muñoz, Luis

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dc.contributor.author	Cortés, Sandra
dc.contributor.author	Zúñiga-Venegas, Liliana A.
dc.contributor.author	Pancetti, Floria
dc.contributor.author	Covarrubias, Alejandra
dc.contributor.author	Ramírez-Santana, Muriel
dc.contributor.author	Adaros, Héctor
dc.contributor.author	Muñoz, Luis
dc.date.accessioned	2021-12-21T13:05:27Z
dc.date.available	2021-12-21T13:05:27Z
dc.date.issued	2021
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/3639
dc.description.abstract	Chile is a mining country, where waste mining is frequently found in the vicinity of inhabited areas. To explore the association between metal exposure and alterations in glucose metabolism, inflammatory status, and oxidative stress in individuals with chronic exposure to metals, a cross-sectional study was performed with 25 volunteers, between 45–65 years old. Inductive coupled plasma mass spectrometry (ICP-MS) was used to measure urinary levels of total arsenic (As) and its metabolites, cooper, nickel, chromium, and lead. Lipid profile, glucose, and insulin were measured in blood, as well as inflammation (interleukin-6, IL-6) and oxidative stress (8-hydroxy-2′deoxyguanosine, 8-OHdG) markers. Increased levels of Low-density lipoprotein, high-density lipoproteins, cholesterol and 8-OHdG, and the index for homeostasis model assessment—insulin resistance (HOMA-IR) were observed in 72%, 60%, and 56% of the volunteers, respectively. Blood-glucose levels were correlated with dimethylarsinic acid (DMA) (R2 = 0.47, p = 0.019), inorganic As (Asi) (R2 = 0.40, p = 0.012), and Ni (R2 = 0.56; p = 0.044). The models with these compounds explained 72% of the glycemia variability (βDMA = −6.47; βAsi = 6.68; βNi = 6.87). Ni showed a significantly influence on IL-6 variability (β = 0.85: R2 = 0.36). Changes in glycemia could be related to exposure to low levels of Asi and Ni, representing risk factors for metabolic diseases. Body mass index would confuse the relation between IL-6 and Ni levels, probably due to known chronic inflammation present in obese people.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	International Journal of Environmental Research and Public Health, 18(4), 1419	es_CL
dc.subject	Metabolic disorders	es_CL
dc.subject	Metal exposure	es_CL
dc.subject	Glycemia	es_CL
dc.subject	Cholesterol	es_CL
dc.title	A positive relationship between exposure to heavy metals and development of chronic diseases: A case study from Chile	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Medicina	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	www.mdpi.com/1660-4601/18/4/1419	es_CL
dc.ucm.doi	doi.org/10.3390/ijerph18041419	es_CL