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Preclinical and clinical trials of new treatment strategies targeting cancer stem cells in subtypes of breast cancer

dc.contributor.authorLanderos, Natalia
dc.contributor.authorCastillo, Iván
dc.contributor.authorPérez-Castro, Ramón
dc.date.accessioned2023-03-29T12:40:25Z
dc.date.available2023-03-29T12:40:25Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4601
dc.description.abstractBreast cancer (BC) can be classified into various histological subtypes, each associated with different prognoses and treatment options, including surgery, radiation, chemotherapy, and endocrine therapy. Despite advances in this area, many patients still face treatment failure, the risk of metastasis, and disease recurrence, which can ultimately lead to death. Mammary tumors, like other solid tumors, contain a population of small cells known as cancer stem-like cells (CSCs) that have high tumorigenic potential and are involved in cancer initiation, progression, metastasis, tumor recurrence, and resistance to therapy. Therefore, designing therapies specifically targeting at CSCs could help to control the growth of this cell population, leading to increased survival rates for BC patients. In this review, we discuss the characteristics of CSCs, their surface biomarkers, and the active signaling pathways associated with the acquisition of stemness in BC. We also cover preclinical and clinical studies that focus on evaluating new therapy systems targeted at CSCs in BC through various combinations of treatments, targeted delivery systems, and potential new drugs that inhibit the properties that allow these cells to survive and proliferate.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceCells, 12(5), 720es_CL
dc.subjectBreast canceres_CL
dc.subjectBiomarkeres_CL
dc.subjectMetastasises_CL
dc.subjectBreast cancer stem cellses_CL
dc.subjectStemnesses_CL
dc.titlePreclinical and clinical trials of new treatment strategies targeting cancer stem cells in subtypes of breast canceres_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/2073-4409/12/5/720es_CL
dc.ucm.doidoi.org/10.3390/cells12050720es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile