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Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants

dc.contributor.authorPetermann-Rocha, Fanny
dc.contributor.authorWirth, Michael D.
dc.contributor.authorBoonpor, Jirapitcha
dc.contributor.authorParra‑Soto, Solange
dc.contributor.authorZhou, Ziyi
dc.contributor.authorMathers, John
dc.contributor.authorLivingstone, Katherine M.
dc.contributor.authorForrest, Ewan
dc.contributor.authorPell, J.P.
dc.contributor.authorHo, Frederick
dc.contributor.authorHébert, James R
dc.contributor.authorCelis-Morales, Carlos
dc.date.accessioned2023-04-25T14:12:06Z
dc.date.available2023-04-25T14:12:06Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4706
dc.description.abstractBackground Although non-alcoholic fatty liver disease (NAFLD) is linked to infammation, whether an infammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted Diet Infammatory Index (E-DII) score and severe NAFLD using UK Biobank. Methods This prospective cohort study included 171,544 UK Biobank participants. The E-DII score was computed using 18 food parameters. Associations between the E-DII and incident severe NAFLD (defned as hospital admission or death) were frst investigated by E-DII categories (very/moderately anti-infammatory [E-DII< −1], neutral [E-DII−1 to 1] and very/moderately pro-infammatory [E-DII>1]) using Cox proportional hazard models. Nonlinear associa‑ tions were investigated using penalised cubic splines ftted into the Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. Results Over a median follow-up of 10.2 years, 1489 participants developed severe NAFLD. After adjusting for confounders, individuals in the very/moderately pro-infammatory category had a higher risk (HR: 1.19 [95% CI: 1.03 to 1.38]) of incident severe NAFLD compared with those in the very/moderately anti-infammatory category. There was some evidence of nonlinearity between the E-DII score and severe NAFLD. Conclusions Pro-infammatory diets were associated with a higher risk of severe NAFLD independent of confound‑ ers such as the components of the metabolic syndrome. Considering there is no recommended treatment for the disease, our fndings suggest a potential means to lower the risk of NAFLD.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBMC Medicine, 21(1), 123es_CL
dc.subjectDietes_CL
dc.subjectNon-alcoholic fatty liver diseasees_CL
dc.subjectIncidencees_CL
dc.subjectInfammationes_CL
dc.subjectProspective studieses_CL
dc.titleAssociations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participantses_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uribmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02793-yes_CL
dc.ucm.doidoi.org/10.1186/s12916-023-02793-yes_CL


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