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Trimethylsilyl azide-promoted acid-amine coupling: a facile one-pot route to amides from carboxylic acids and amines
| dc.contributor.author | Tangella, Yellaiah | |
| dc.contributor.author | Prakash Soni, Jay | |
| dc.contributor.author | Shankaraiah, Nagula | |
| dc.contributor.author | abril, diana | |
| dc.contributor.author | Sathish, Manda | |
| dc.date.accessioned | 2023-05-02T19:08:31Z | |
| dc.date.available | 2023-05-02T19:08:31Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/4740 | |
| dc.description.abstract | A versatile and efficient one-pot protocol has been developed for the synthesis of amides from easily accessible carboxylic acids and amines by employing trimethylsilyl azide as a promoter at room temperature. This reaction proceeds via an in situ generated acyl azide intermediates followed by the nucleophilic substitution of amines. Notably, most of the desired amides were obtained by simple filtration in excellent yields. The significant advantages like metal-free mild reaction conditions, higher yields, easily removable volatile byproducts, operational simplicity, and broad substrate scope make the transformation a useful contribution for the synthesis of biologically important amides. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Arkivoc, 2023(6), 202211914 | es_CL |
| dc.subject | Amide coupling | es_CL |
| dc.subject | Amine | es_CL |
| dc.subject | Peptide | es_CL |
| dc.subject | Carboxylic acid | es_CL |
| dc.subject | Trimethylsilyl azide | es_CL |
| dc.title | Trimethylsilyl azide-promoted acid-amine coupling: a facile one-pot route to amides from carboxylic acids and amines | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Ciencias Básicas | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p011.914 | es_CL |
| dc.ucm.doi | doi.org/10.24820/ark.5550190.p011.914 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile