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Synthesis of lactam-bridged and lipidated cyclo-peptides as promising anti-phytopathogenic agents

dc.contributor.authorVasco, Aldrin V.
dc.contributor.authorBrode, Martina
dc.contributor.authorMéndez, Yanira
dc.contributor.authorValdés-Lizama, Oscar
dc.contributor.authorRivera, Daniel G.
dc.contributor.authorWessjohann, Ludger A.
dc.date.accessioned2023-05-16T14:45:32Z
dc.date.available2023-05-16T14:45:32Z
dc.date.issued2020
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4777
dc.description.abstractAntimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is not prone to fast resistance formation, and often show organism-type selectivity. Additional modes of action commonly complement the bioactivity profiles of such compounds. The present work describes a multicomponent-based methodology for the synthesis of cyclic polycationic lipopeptides with stabilized helical structures. The protocol comprises an on solid support Ugi-4-component macrocyclization in the presence of a lipidic isocyanide. Circular dichroism was employed to study the influence of both macrocyclization and lipidation on the amphiphilic helical structure in water and micellar media. First bioactivity studies against model phytopathogens demonstrated a positive effect of the lipidation on the antimicrobial activity.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceMolecules, 25(4), 811es_CL
dc.subjectPeptide cyclizationes_CL
dc.subjectAntimicrobial peptideses_CL
dc.subjectMulticomponent reactionses_CL
dc.subjectLipopeptideses_CL
dc.subjectFungicideses_CL
dc.subjectAntimycoticses_CL
dc.subjectPlant pathogenses_CL
dc.titleSynthesis of lactam-bridged and lipidated cyclo-peptides as promising anti-phytopathogenic agentses_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.doidoi.org/10.3390/molecules25040811es_CL


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