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High burden of intestinal colonization with antimicrobial-resistant bacteria in Chile: an antibiotic resistance in communities and hospitals (ARCH) study

dc.contributor.authorAraos, Rafael
dc.contributor.authorSmith, Rachel
dc.contributor.authorStyczynski, Ashley
dc.contributor.authorSánchez, Felipe
dc.contributor.authorAcevedo, Johanna
dc.contributor.authorMaureira, Lea
dc.contributor.authorParedes, Catalina
dc.contributor.authorGonzález, Maite
dc.contributor.authorRivas, Lina
dc.contributor.authorSpencer-Sandino, Maria
dc.contributor.authorPeters, Anne
dc.contributor.authorKhan, A. I.
dc.contributor.authorSepulveda, Dino
dc.contributor.authorRojas Wettig, Loreto
dc.contributor.authorRioseco, Maria L.
dc.contributor.authorUsedo, Pedro
dc.contributor.authorRojas Soto, Pamela
dc.contributor.authorHuidobro, Laura Andrea
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorPark, Benjamin J.
dc.contributor.authorUndurraga, Eduardo
dc.contributor.authorD’Agata, Erika M. C
dc.contributor.authorJara, Alejandro
dc.contributor.authorMunita, Jose
dc.date.accessioned2023-08-17T18:01:23Z
dc.date.available2023-08-17T18:01:23Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4905
dc.description.abstractBackground Antimicrobial resistance is a global threat, heavily impacting low- and middle-income countries. This study estimated antimicrobial-resistant gram-negative bacteria (GNB) fecal colonization prevalence in hospitalized and community-dwelling adults in Chile before the coronavirus disease 2019 pandemic. Methods From December 2018 to May 2019, we enrolled hospitalized adults in 4 public hospitals and community dwellers from central Chile, who provided fecal specimens and epidemiological information. Samples were plated onto MacConkey agar with ciprofloxacin or ceftazidime added. All recovered morphotypes were identified and characterized according to the following phenotypes: fluoroquinolone-resistant (FQR), extended-spectrum cephalosporin-resistant (ESCR), carbapenem-resistant (CR), or multidrug-resistant (MDR; as per Centers for Disease Control and Prevention criteria) GNB. Categories were not mutually exclusive. Results A total of 775 hospitalized adults and 357 community dwellers were enrolled. Among hospitalized subjects, the prevalence of colonization with FQR, ESCR, CR, or MDR-GNB was 46.4% (95% confidence interval [CI], 42.9–50.0), 41.2% (95% CI, 37.7–44.6), 14.5% (95% CI, 12.0–16.9), and 26.3% (95% CI, 23.2–29.4). In the community, the prevalence of FQR, ESCR, CR, and MDR-GNB colonization was 39.5% (95% CI, 34.4–44.6), 28.9% (95% CI, 24.2–33.6), 5.6% (95% CI, 3.2–8.0), and 4.8% (95% CI, 2.6–7.0), respectively. Conclusions A high burden of antimicrobial-resistant GNB colonization was observed in this sample of hospitalized and community-dwelling adults, suggesting that the community is a relevant source of antibiotic resistance. Efforts are needed to understand the relatedness between resistant strains circulating in the community and hospitals.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceClinical Infectious Diseases, 77(Suppl. 1), S75-S81es_CL
dc.subjectAntimicrobial-resistancees_CL
dc.subjectColonizationes_CL
dc.subjectGram-negativees_CL
dc.subjectCommunityes_CL
dc.subjectLatin Americaes_CL
dc.titleHigh burden of intestinal colonization with antimicrobial-resistant bacteria in Chile: an antibiotic resistance in communities and hospitals (ARCH) studyes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uriacademic.oup.com/cid/article/77/Supplement_1/S75/7219528?login=falsees_CL
dc.ucm.doidoi.org/10.1093/cid/ciad283es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile