Schizophrenia and types of stroke: A mendelian randomization study

Nakada, Shinya; Ho, Frederick; Celis-Morales, Carlos; Pell, Jill P.

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dc.contributor.author	Nakada, Shinya
dc.contributor.author	Ho, Frederick
dc.contributor.author	Celis-Morales, Carlos
dc.contributor.author	Pell, Jill P.
dc.date.accessioned	2024-04-23T15:33:34Z
dc.date.available	2024-04-23T15:33:34Z
dc.date.issued	2024
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/5335
dc.description.abstract	BACKGROUND: Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes. METHODS AND RESULTS: Two-sample Mendelian randomization analyses were conducted. The summary-level data (restricted to European ancestry) were obtained for schizophrenia and stroke: ischemic stroke, large-artery stroke, small-vessel stroke, cardioembolic stroke, and intracerebral hemorrhage. The associations between schizophrenia and each outcome were analyzed by an inverse variance weighting method primarily and Mendelian randomization Egger, weighted median, and weighted mode subsequently. The presence of pleiotropy was also tested by Cochran Q statistic, I 2 index, and Mendelian randomization Egger intercept with scatter and funnel plots. We found associations between schizophrenia and cardioembolic stroke (odds ratio [OR], 1.070 [95% CI, 1.023–1.119]) and intracerebral hemorrhage (OR, 1.089 [95% CI, 1.005–1.180]) using inverse variance weighting. Little evidence of associations with the other stroke subtypes was found. Different Mendelian randomization methods corroborated the association with cardioembolic stroke but not intracerebral hemorrhage. CONCLUSIONS: We have provided evidence of a potentially causal association between schizophrenia and cardioembolic stroke. Our findings suggest that cardiac evaluation should be considered for those with schizophrenia.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	Journal of the American Heart Association, 13(5), e032011	es_CL
dc.subject	Hemorrhagic	es_CL
dc.subject	Ischemic	es_CL
dc.subject	Mendelian randomization	es_CL
dc.subject	Schizophrenia	es_CL
dc.subject	Stroke	es_CL
dc.title	Schizophrenia and types of stroke: A mendelian randomization study	es_CL
dc.type	Article	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	ahajournals.org/doi/10.1161/JAHA.123.032011	es_CL
dc.ucm.doi	doi.org/10.1161/JAHA.123.032011	es_CL