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Prospective cohort study identifies medical predictors of treatment-related oral toxicities in oral and oropharyngeal cancer patients

dc.contributor.authorRodrigues-Oliveira, Leticia
dc.contributor.authorRivera, César
dc.contributor.authorLópez-Cortés, Xaviera A.
dc.contributor.authorPerez Mak, Milena
dc.contributor.authorMores, Ana Leticia
dc.contributor.authorMigliorati, Cesar Augusto
dc.contributor.authorQuerido de Oliveira, Maria Cecília
dc.contributor.authorPalmier, Natalia Rangel
dc.contributor.authorGueiros, Luiz Alcino
dc.contributor.authorVargas, Pablo Agustin
dc.contributor.authorBrandão, Thaís Bianca
dc.contributor.authorSantos-Silva, Alan Roger
dc.contributor.authorPrado-Ribeiro, Ana Carolina
dc.date.accessioned2024-05-13T18:29:05Z
dc.date.available2024-05-13T18:29:05Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5391
dc.description.abstractThe dental treatment of patients with oral cavity and oropharyngeal squamous cell carcinoma (OOPSCC) may be challenging for dentists. This study aimed to characterize systemic changes in patients with OOPSCC undergoing dental treatment prior to cancer therapy, with a specific focus on laboratory assessments. The primary objectives included identifying potential adverse events, such as infections or bleeding, resulting from dental procedures. Additionally, the study aimed to correlate baseline patient characteristics with treatment-related toxicities. This was a prospective cohort study that included 110 OOPSCC patients referred to the Dental Oncology Service at São Paulo State Cancer Institute, Brazil, between November/2019 and December/2020. Comorbidities, sociodemographic data, medication in use, cancer treatment-related toxicities, and altered laboratory tests results were correlated. The most common comorbidities and altered laboratory results were hypertension, dyslipidemia, diabetes, as well as elevated levels of C-reactive protein, hemoglobin, and hematocrit. Toxicities exhibited a progressive pattern over time, encompassing oral mucositis (OM), xerostomia, dysphagia, dysgeusia, trismus, and radiodermatitis. No correlation between comorbidities and cancer treatment-related toxicities, a positive correlation between medications in use and OM, and a negative correlation between medications and dysgeusia were found. OM was associated with altered thyroxine (T4) and free thyroxine (FT4), calcium, urea, creatinine, alkaline phosphatase, and syphilis. Family income and housing were OM predictors. Altered T4/FT4/urea/calcium/alkaline phosphatase/creatinine/syphilis may be useful clinical predictors of OM. Despite the elevated prevalence of comorbidities and abnormal laboratory findings, dental treatment prior to cancer treatment yielded no adverse events.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceDentistry Journal, 12(4), 89es_CL
dc.subjectMedical historyes_CL
dc.subjectMedical examinationes_CL
dc.subjectDental carees_CL
dc.subjectComorbidityes_CL
dc.subjectOral canceres_CL
dc.subjectOropharyngeal canceres_CL
dc.titleProspective cohort study identifies medical predictors of treatment-related oral toxicities in oral and oropharyngeal cancer patientses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias de la Ingenieríaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.urimdpi.com/2304-6767/12/4/89es_CL
dc.ucm.doidoi.org/10.3390/dj12040089es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile