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Association between the AHA Life's Essential 8 score and incident all-cause dementia: a prospective cohort study from UK biobank
| dc.contributor.author | Petermann-Rocha, Fanny | |
| dc.contributor.author | Deo, Salil | |
| dc.contributor.author | Lyall, Donald | |
| dc.contributor.author | Orkaby, Ariela R. | |
| dc.contributor.author | Quinn, Terence J. | |
| dc.contributor.author | Sattar, Naveed | |
| dc.contributor.author | Celis-Morales, Carlos | |
| dc.contributor.author | Pell, Jill P. | |
| dc.contributor.author | Ho, Frederick | |
| dc.date.accessioned | 2024-08-07T15:04:41Z | |
| dc.date.available | 2024-08-07T15:04:41Z | |
| dc.date.issued | 2023 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/5589 | |
| dc.description.abstract | This study aimed to investigate the association between the Life's Essential 8 (LE8) score and incident all-cause dementia (including Alzheimer's disease [AD] and vascular dementia) in UK Biobank. A total of 259,718 participants were included in this prospective study. Smoking, non-HDL cholesterol, blood pressure, body mass index, HbA1c, physical activity, diet, and sleep were used to create the Life's Essential 8 (LE8) score. Associations between the score (both continuous and as quartiles) and outcomes were investigated using adjusted Cox proportional hazard models. The potential impact fractions of 2 scenarios and the rate advancement periods were also calculated. Over a median follow-up of 10.6 years, 4958 participants were diagnosed with any dementia. Higher LE8 scores were associated with lower risk of all-cause and vascular dementia in an exponential decay pattern. Compared with individuals in the healthiest quartile, those in the least healthy quartile had a higher risk of all-cause dementia (HR: 1.50 [95% CI: 1.37-1.65] and vascular dementia (HR: 1.86 [1.44-2.42]). A targeted intervention that increased the score by 10-points among individuals in the lowest quartile could have prevented 6.8% of all-cause dementia cases. Individuals in the least healthy LE8 quartile might develop all-cause dementia 2.45 years earlier than their counterparts. In conclusion, individuals with higher LE8 scores had lower risk of all-cause and vascular dementia. Because of nonlinear associations, interventions targeted at the least healthy individuals might produce greater population-level benefits. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Current Problems in Cardiology, 48(11), 101934 | es_CL |
| dc.title | Association between the AHA Life's Essential 8 score and incident all-cause dementia: a prospective cohort study from UK biobank | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | sciencedirect.ucm.elogim.com/science/article/pii/S0146280623003511?via%3Dihub | es_CL |
| dc.ucm.doi | doi.org/10.1016/j.cpcardiol.2023.101934 | es_CL |
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Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile