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Main methods and tools for peptide development based on protein-protein interactions (PPIs)
| dc.contributor.author | Baeza, Javiera | |
| dc.contributor.author | Bedoya, Mauricio | |
| dc.contributor.author | Cruz, Pablo | |
| dc.contributor.author | Ojeda, Paola | |
| dc.contributor.author | Adasme-Carreño, Francisco | |
| dc.contributor.author | Cerda, Oscar | |
| dc.contributor.author | González, Wendy | |
| dc.date.accessioned | 2025-06-12T14:10:40Z | |
| dc.date.available | 2025-06-12T14:10:40Z | |
| dc.date.issued | 2025 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/6116 | |
| dc.description.abstract | Protein-protein interactions (PPIs) regulate essential physiological and pathological processes. Due to their large and shallow binding surfaces, PPIs are often considered challenging drug targets for small molecules. Peptides offer a viable alternative, as they can bind these targets, acting as regulators or mimicking interaction partners. This review focuses on competitive peptides, a class of orthosteric modulators that disrupt PPI formation. We provide a concise yet comprehensive overview of recent advancements in in-silico peptide design, highlighting computational strategies that have improved the efficiency and accuracy of PPI-targeting peptides. Additionally, we examine cutting-edge experimental methods for evaluating PPI-based peptides. By exploring the interplay between computational design and experimental validation, this review presents a structured framework for developing effective peptide therapeutics targeting PPIs in various diseases. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | Biochemical and Biophysical Research Communications, 758, 151623 | es_CL |
| dc.subject | Competitive peptides | es_CL |
| dc.subject | Protein-protein interactions | es_CL |
| dc.subject | In silico peptide design | es_CL |
| dc.subject | In vitro peptide evaluation | es_CL |
| dc.title | Main methods and tools for peptide development based on protein-protein interactions (PPIs) | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.facultad | Facultad de Medicina | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | sciencedirect.ucm.elogim.com/science/article/pii/S0006291X25003377?via%3Dihub | es_CL |
| dc.ucm.doi | doi.org/10.1016/j.bbrc.2025.151623 | es_CL |
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